Which side effect of opioids is not time-limited?

The correct response highlights an important aspect of opioid use and its effects on the body. Opioid-induced constipation is significant because it is a side effect that does not diminish over time with continued use of the medication. Unlike some other side effects of opioids, such as nausea, respiratory depression, and somnolence, which may decrease as the body develops tolerance to opioids, constipation remains a persistent issue that often requires ongoing management.

In patients receiving opioids for chronic pain or palliative care, the risk of constipation is a critical consideration. This side effect necessitates proactive treatment strategies, such as regular use of laxatives or other medications, as it will not resolve without intervention, even if the patient has been on opioids for an extended period. Therefore, understanding the long-term implications of opioid-induced constipation is vital for effective patient management in hospice and palliative care settings.