Which antiepileptic drug is noted for better bioavailability and can be administered twice daily?

Pregabalin is recognized for having improved bioavailability compared to many other antiepileptic medications. This characteristic allows for a more predictable absorption and effect when administered. Pregabalin's bioavailability can reach up to 90%, making it a favorable choice when considering dosing regimens.

Additionally, pregabalin is typically administered twice daily, aligning well with patient preferences and compliance. This dosing schedule can enhance patient adherence to the treatment plan, as it simplifies medication management and reinforces routine.

Gabapentin, while also effective, has a relatively lower bioavailability and its absorption can be affected by the dose, which may complicate treatment consistency. Carbamazepine and lamotrigine, on the other hand, tend to require more frequent dosing or have more complex pharmacokinetics, which may not make them as straightforward for twice-daily administration as pregabalin. Thus, pregabalin is ideally suited for the criteria outlined in the question.